The actual process is complex, but it includes your innate immunity, which is your body's initial response to an invader, and your adaptive immunity, where your body sends more specialized immune cells to target a particular pathogen. And to get through this pandemic at your healthiest, don't miss these 35 Places You're Most Likely to Catch COVID. That's because your lymph nodes are where a lot of the action takes place when you mount an immune response and produce antibodies to fight infection, so the ones closest to the site of the. And venous thromboembolic events (blood clots). Indigestion, heartburn or abdominal pain are symptoms of COVID-19, but also of a heart attack. Federal government websites often end in .gov or .mil. So, Can You Have an Allergic Reaction to a Virus Like COVID-19? Swollen lymph nodes can signal infection. New York, N.Y.: McGraw-Hill Education; 2015. http://accessmedicine.mhmedical.com. Jordana Haber, MD, MACM, is an emergency physician at University Medical Center in Las Vegas, where she serves as director of Clinical Education and Simulation for the residency program. Feldman M, et al. Heart failure: Could a low sodium diet sometimes do more harm than good? Researchers have established a link between swollen lymph nodes and COVID-19, both as a side effect of vaccination and a symptom of the condition. Paul Ridker, the Eugene Braunwald Professor of Medicine at Brigham and Women's Hospital, told the Gazette: "It's like one big stress test for the heart." A single copy of these materials may be reprinted for noncommercial personal use only. Previous studies on SARS-CoV1 found an increase in osteonecrosis 3-36 months after infection, and it is still unclear if this was related to the use of corticosteroids or to the virus itself. In the absence of clinical evidence of swelling during the laboratory evaluation, we suspected deep vein thrombosis. They should seek medical care immediately if abdominal pain, chest pain, or other symptoms also develop. Its a good question and not an easy one to answer. Lymphatic drainage (a form of self-massage). We know how important making choices about your overall health is, and we strive to provide you with the best information possible. Sometimes, its a result of fluid buildup after a long day on your feet. And though this hasn't been widely reported with COVID-19, "it might theoretically be possible," said Dr. Kulkarni. Macmillan, C. (2021). Not to mention, "Some of the medications utilized to treat COVID-19"like hydroxychloroquine"also have potential cardiac complications" related to your heartbeat, says the new research. There is also a possible link between swollen lymph nodes and COVID-19. A. from Wuhan, China, where the virus originated, for example, found COVID-19 patients had myocardial injuries, and the patients had these commonalities: and underlying cardiovascular-related comorbidities. "In our cohort none of the five patients presenting with complaints pertaining to leg symptoms only, such as pain or discoloration, without systemic symptoms sustained amputation or died," Dr. Goldman said. Blood clot, Covid-19, Health News. During the peak of the COVID-19 pandemic in New York City, radiologists at the city's Montefiore Medical Center observed an increase in patients testing positive for lower extremity arterial thrombosis on CT angiography exams. American College of Emergency Physicians. Call your medical professional if you can't breathe, no matter what. Actually, it's in the pits, the armpits. doi: 10.1136/bmj.n1931. In a study published in 2021, the authors mentioned that swollen neck lymph nodes. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, multi-system inflammatory syndrome in children (MIS-C), https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846295/, https://www.ncbi.nlm.nih.gov/books/NBK513250/, https://www.michigan.gov/-/media/Project/Websites/coronavirus/Folder1/MIS-C_for_EMS.pdf?rev=86ff16c350f14db595edd180e0eaa97a, https://www.yalemedicine.org/news/vaccine-reactions, https://www.ncbi.nlm.nih.gov/books/NBK558918/, https://www.nhs.uk/conditions/swollen-glands/, https://www.nhsinform.scot/illnesses-and-conditions/glands/swollen-glands, https://pubs.rsna.org/doi/10.1148/radiol.213227. The lesions are caused by an inflammatory reaction and may resemble chilblains or perniosis.AP In the first week of the virus, most COVID-19 patients will have some variation of the hallmarks: an unexplained fever, sore throat, runny nose, headache, a dry cough and fatigue. Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-19 vaccination; a systematic review. Feeling achy. Talk with a healthcare provider, though, if your swelling: Swollen legs are often a sign of a bigger problem, states Dr. Caputo. Edema is a medical . Achilles tendinitis is an overuse injury of the band of tissue that connects your calf muscles at the back of the lower leg to your heel bone. Never give aspirin for fever, pain or within 6 weeks of getting the shot. Read here to know more about the signs of a blood clot, and how COVID-19 may impact your blood flow. Some causes of this swelling, such as standing or . First dose ChAdOx1 and BNT162b2 COVID-19 vaccinations and cerebral venous sinus thrombosis: A pooled self-controlled case series study of 11.6 million individuals in England, Scotland, and Wales. Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study. Now, practicing yoga and meditation, and working towards living in a chemical-free home, her experiences make her the perfect conduit to help others live and feel better naturally. June 18, 2021. by John Anderer. Preliminary outcomes of combined surgical approach for lower extremity lymphedema: supraclavicular lymph node transfer and lymphaticovenular anastomosis. When your heart is having trouble working, it takes more effort for it to pump blood. If you press on your legs and leave a dent, chances are your legs are swollen. Unauthorized use of these marks is strictly prohibited. In that case, in terms of a histamine response to a virus like COVID-19, it's possible that the body could produce enough histamine to mimic an allergic reaction in addition to fighting off the virus. Results from following the information contained on EasyHealthOptions.com will vary from individual to individual. Signs of a heart attack, according to the Mayo Clinic, are the classic: "Pressure, tightness, pain, or a squeezing or aching sensation in your chest or arms that may spread to your neck, jaw or back. if( navigator.sendBeacon ) { We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. The https:// ensures that you are connecting to the 5 Skin Conditions Dermatologists Say Are Linked To COVID-19. Hippisley-Cox J, Patone M, Mei XW, Saatci D, Dixon S, Khunti K, Zaccardi F, Watkinson P, Shankar-Hari M, Doidge J, Harrison DA, Griffin SJ, Sheikh A, Coupland CAC. https://www.clinicalkey.com. sharing sensitive information, make sure youre on a federal The exact reason for this is unclear, but Dr. Parikh said that it's thought that "over-stimulation of the immune system can cause immune complexes that trigger histamine release.". Inflammation attacks joint tissues, causing fluid in your joints, swelling . Deep vein thrombosis (DVT) is a blood clot that forms in a vein of your body, usually (but not always) in your pelvis, thigh or lower leg. Your legs are looking like they belong to the Stay Puft Marshmallow Man. Paul Ridker, the Eugene Braunwald Professor of Medicine at Brigham and Women's Hospital, told the Gazette: "It's like one big stress test for the heart." She says she was put on high flow oxygen, due to heavy breathing complications. https://www.uptodate.com/contents/search. Mayo Clinic does not endorse companies or products. These can affect hands or feet, or both at the same time. Medical experts spread word about harmless COVID-19 vaccine reactions. Philadelphia, Pa.: Saunders Elsevier; 2016. https://www.clinicalkey.com. Swollen lymph nodes can be a side effect of COVID-19 vaccination or a symptom of the illness. When your heart is having trouble working, it takes more effort for it to pump blood. 2 Backache While muscle aches and pains tend to come with the COVID. The authors have no potential conflicts of interest relevant to this article to report. Watch out for any signs of fluid retention, such as swelling of your legs or feet, too. All Rights Reserved. Give acetaminophen or ibuprofen for fever over 102 F (39C). HHS Vulnerability Disclosure, Help petechia (without a decrease in platelet count). Other symptoms include shortness of breath or difficulty breathing, muscle aches, chills, sore throat, headache, or chest pain. Mayo Clinic, Rochester, Minn. June 14, 2017. That swelling, called edema, strikes when fluid builds up in your feet and legs. 11th ed. You might experience symptoms of an allergic reactionbut not due to the virus itself. When youre traveling, get up frequently to stretch and move. Managing Inflammation. See this image and copyright information in PMC. With a blood clot, "the pain often starts in your calf and can feel like cramping or soreness," says the Mayo Clinic. 2022 Jan 1;399(10319):36-49. doi: 10.1016/S0140-6736(21)02718-5. official website and that any information you provide is encrypted Before Note: Deep vein thrombosis can also exhibit no symptoms. A. from Wuhan, China, where the virus originated, for example, found COVID-19 patients had myocardial injuries, and the patients had these commonalities: "First, people with preexisting heart disease are at a greater risk for severe cardiovascular and respiratory complications from COVID-19," reported the, has shown that infection with the influenza virus poses a more severe threat for people with heart disease than those without cardiac problems. Even Mild COVID-19 Infections Increase Risk of Type 2 Diabetes, Research Shows. Researchers have found "severe or critical cases" of heart issues "account for less than 20% of patients with COVID-19." J Plast Surg Hand Surg 2021;019. Epub 2022 Oct 27. Death or limb amputation was more common in the COVID-19 patients. RELATED: Simple Ways to Avoid a Heart Attack, According to Doctors. No, you can'tbut it is possible to experience symptoms similar to an allergic reaction. Here is her long COVID journey A lot of people had close encounter with COVID in 2020 and sadly, many known ones fought unsuccessfully. By American Roentgen Ray Society June 23, 2022. The most common are: More serious and less common causes include: Cancer can also cause swollen lymph nodes. According to Dr. Parikh, this study points to several important ways that both you and your doctor can take action to prevent serious complications, or possibly save your life. COVID-19 infections have resulted in cervical lymphadenopathy, or swollen lymph nodes in the neck, as well. It's not uncommon for COVID-19 to cause issues such as a loss of taste and smell, dizziness, or fatigue in . Since COVID-19 can infect your lungs, the shortness of breath can be confusingis it COVID-19 or a heart attack or both? From the testing data for the vaccine, we noted that lymph node swelling was a fairly common side effect of both the Moderna and Pfizer vaccines. It is not intended to provide medical or other professional advice. If you find it difficult to put on or take off your shoes or socks, it could be a hint that something is amiss. Research also shows that heart attacks can actually be brought on by respiratory infections such as the flu. In fact sheets describing each vaccine, manufacturers listed additional possible side effectsincluding diarrhea, joint pain, swollen lymph nodes, hives, rashes and facial swellingand noted. A person should seek medical attention if they experience any other symptoms or notice the swelling does not improve. Wilkinson JM (expert opinion). Of course, any major symptoms such as confusion, seizures, or a coma requires immediate medical attention. Materials provided by Radiological Society of North America. 10th ed. In the legs, swelling is the most common sign of a blood clot, Dr. Tsuang says. With a blood clot: "You may have a persistent, throbbing cramp-like feeling in the leg. Additionally, your immune system is made to recognize invaders (i.e., unhealthy cells), including viruses and bacteria, and begin an immune response to try to rid them. The reactions,. Nearly a. Deep vein thrombosis more than two weeks after vaccination against COVID-19. However, sometimes the body can overreact to a harmless substance (think: allergens like pollen, latex, mold, dust mites, insect stings, or certain foods), per the American Academy of Allergy, Asthma & Immunology (AAAAI), and cause a release of chemicals called histamines, which can trigger inflammation. One sign of a blood clot is swelling in the legbut usually not both legs. You likely think of COVID-19 as a "respiratory disease," but the coronavirus has been shown to infect the heart, as well as the lungs, and research reveals just how much damage it can do. Lessons: Then, almost a month later, a weird numbness that spread down the right side of her body. 2021 Aug 26;374:n1931. For example, one of those messages includes ensuring that stomach cells produce stomach acid. Bookshelf Elsevier Point of Care. Swollen legs may be a sign of heart failure, kidney failure, or liver failure. RELATED: COVID Symptoms Usually Appear in This Order, Study Finds, "If a clot plugs up veins in your arms or legs, they may look bluish or reddish," explains WebMD. Its uses now run the gamut from varicose veins to circulation. Frequently these symptoms of leg ischemia, a condition in which blood flow to the lower extremities is restricted, were accompanied by respiratory distress, cough, fever and altered mental status. 2017;64:525. Dr. Parikh mentioned that it's possible to have hives, itchy rashes, and swelling with every virusincluding COVID-19. Lymphedema of the Arm after COVID-19 Vaccination in a Patient with Hidden Breast Cancer and Paraneoplastic Dermatomyositis. Lymphatic drainage massage, also known as manual lymphatic drainage, is a gentle form of massage used to relieve painful swelling in your arms and legs caused by lymphedema. In these conditions, there is too much fluid in the body, and it collects in the legs. And those can range from no big deal to very serious. https://nei.nih.gov. You may also experience pain or tenderness when standing or walking. doi: 10.1080/2000656X.2021.1964980. The cholesterol-lowering food supplement that tames anxiety, Rutgers Reports First Instance of COVID-19 Triggering Recurrent Blood Clots in Arms, Recurrence of Upper Extremity Deep Vein Thrombosis Secondary to COVID-19. Schmitt BD. Skin that looks puffy, stretched or shiny. Epub ahead of print. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Accessed Oct. 30, 2017. Editors note: Have you heard of EDTA chelation therapy? There's good news about "Moderna arm," the raised, sometimes itchy red rash some people get a week or so after being vaccinated with Moderna's COVID-19 vaccine. Their findings confirm what other researchers have found. Semin Thromb Hemost 2020;46:76371. swelling. The World Health Organization has listed three of the most common symptoms of COVID-19 as fever, a dry cough and tiredness. A person can also try home remedies such as using a warm compress, taking pain reliever medications, and having plenty of fluids and rest. People can use warm compresses or heating pads to ease soreness in swollen areas. According to the American Academy of Orthopaedic Surgeons, this is unlikely to occur. https://orthoinfo.aaos.org. } else { It could be your feet need a rest, but swollen legs may also be a sign of a serious condition. 7th ed. Disclaimer. Radiological Society of North America. Joyce Hollman is a writer based in Kennebunk, Maine, specializing in the medical/healthcare and natural/alternative health space. The site is secure. Her mother called 911, and she was taken to the hospital. Some information may be out of date. ", RELATED: The New COVID Symptom Every Woman Needs to Know. "Similarly, research has shown that infection with the influenza virus poses a more severe threat for people with heart disease than those without cardiac problems. ", RELATED: The New COVID Symptom Every Woman Needs to Know. "Awareness of lower extremity arterial thrombosis as a possible complication of COVID-19 infection is important for all providers who take care of these patients, because early diagnosis is usually crucial for limb preservation in lower extremity ischemia," she said. One sign of a blood clot is swelling in the legbut usually not both legs. ScienceDaily, 16 July 2020. PMC BMJ. Fever. New research has discovered that axillary lymphadenopathy, a type of swelling in the armpits, detected after COVID-19 mRNA vaccination lasts longer than reported in initial vaccine clinical trials. Chilblains develops when you're exposed to cold temperatures. But it's not clear how common COVID toes are. In the absence of clinical evidence of swelling during laboratory evaluation or ultrasonographic investigations suggesting deep vein thrombosis, we should consider the possibility of lymphatic disorders. Tendonitis Other signs include rash, red eyes, red cracked lips and a red swollen tongu, joint pain, an enlarged lymph node on the neck and swelling of the hands and feet, sometimes with joint pain. Pain or swelling at the shot site for 1 to 2 days. Accessed Oct. 30, 2017. Radiological Society of North America. Some patients worry that receiving an injection in this area could permanently injure their shoulder. 2023 Mar 1;48(3):264-265. doi: 10.1097/RLU.0000000000004470. This swelling can be uncomfortable and limit your activity. At 2 months follow-up after rehabilitative treatment, the patient's symptoms improved without recurring lymphedema. The red-purple discoloured skin can be painful and itchy, and there are . If you experience any of these symptoms, call your medical professional immediately. Lymphedema often affects people recovering from breast cancer surgery. Pediatric Clinics of North America. Accessed Nov. 11, 2017. Most of the time, even if swollen lymph nodes develop after receiving a COVID vaccine, a person can handle this condition at home. The swelling tends to reduce over time. Superficial venous thrombosisas a possible consequence of ChAdOx1 nCoV-19 vaccine: two case reports. Swollen legs can stem from a wide range of causes, Dr. Caputo reiterates. Also seek immediate medical care if you're pregnant and develop: Find possible causes of foot swelling or leg swelling based on specific factors. The Centers for Disease Control (CDC) identified these symptoms as being part of post-COVID conditions. UpToDate. Please enable it to take advantage of the complete set of features! doi: 10.1002/ccr3.6317. The Pfizer and Moderna vaccines are both mRNA versions of COVID-19 vaccines that are widely available in the United States. Feeling or being sick. Other symptoms that may develop around the same time as the swollen lymph nodes include: Although the number of cases and studies are limited, researchers have found that if a person with COVID has swollen lymph glands, they may also have some other characteristics, such as: In addition to the connection with COVID-19, many other factors can cause swollen lymph nodes. My face was having an allergic reaction to COVID. doi: 10.1371/journal.pmed.1003927. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). It certainly seems like another awful consequence of COVID-19, but is an allergic reaction to the virus a legitimate concern? var xhr = new XMLHttpRequest(); Accessibility Sah MK, Singh BM, Sinha P, Devkota P, Yadav SK, Shrestha J, Shrestha A. J Med Case Rep. 2022 May 7;16(1):182. doi: 10.1186/s13256-022-03407-6. -, Sharifian-Dorche M, Bahmanyar M, Sharifian-Dorche A, et al. If you're experiencing joint pain, it may be caused by inflammation in your body. As a result, you can develop varicose veins and fluid buildup in your legs. Their findings confirm what other researchers have found. The American Journal of Emergency Medicine. Heart, kidney or liver disease. If you experience any of these symptoms, call your medical professional immediately. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Herein, we report a patient who underwent transient lymphedema after vaccination with BNT16b2. Congestive heart failure, kidney disease and liver disease can all cause swelling in your legs. Some people who recently got a booster dose of Covid-19 vaccine are noticing swollen lymph nodes. It also looks at other causes of swollen lymph nodes, home remedies, and when to contact a doctor. Abdominal pain mimics. National Eye Institute. Injury, infection, heart failure, kidney disease, and other underlying health conditions can all cause swelling in the legs and ankles. (A) A 79-year-old woman manifested bilateral lower extremity swelling, MeSH Credit: CaptureIt / Alamy Stock Photo https://www.alamy.com/stock-photo-swollen-puffy-feet-toes-and-ankles-of-adult-female-woman-after-an-16909905.html?pv=1&stamp=2 . GOOCHLAND COUNTY, Va. ( WRIC) A Goochland County man suffered a severe reaction after getting his COVID-19 vaccine and VCU doctors believe it was a direct result of the shot. A team of Rutgers scientists made this discovery while studying a group of patients who were admitted to the Robert Wood Johnson Hospital during the first wave of the pandemic, from March through May of 2020. These are health complications that occur or remain at least four or more weeks after. COVID-19 is associated with life-threatening blood clots in the arteries of the legs, according to a study published in Radiology. Note: Deep vein thrombosis can also exhibit no symptoms. Symptoms include: smooth or patchy redness, bluish or purple discoloration on the skin of the lower extremities. If you test positive for COVID-19, seek medical attention IMMEDIATELY if you experience shortness of breath (a sign of declining oxygen levels) or any unexplained swelling. Mayo Clinic, Rochester, Minn. Aug. 28, 2017. Products mentioned are not intended to diagnose, treat, cure or prevent any disease. 2022 Jul 30;10(8):1219. doi: 10.3390/vaccines10081219. Summary. Hence the increased sweat. As an Amazon Associate, Easy Health Options may earn from qualifying purchases. ScienceDaily. COVID-19's association with lower extremity arterial thrombosis is likely related to a combination of factors, Dr. Goldman said, including an increased tendency of the blood to clot, damage to the lining of the arteries, and immune reactions tied to the SARS-CoV-2 virus and COVID-19 infection. Signs of a heart attack, according to the Mayo Clinic, are the classic: "Pressure, tightness, pain, or a squeezing or aching sensation in your chest or arms that may spread to your neck, jaw or back. "For comparison, the rate of both amputation and death was only 3% among controls. Recently, skin lesions have been described amongst COVID-19 patients, possibly being an indicator of mild infection amongst those previously thought asymptomatic, and additionally may be an. A new Northwestern Medicine study shows how advanced imaging technology can pinpoint what may have caused patients' nerve damage and help determine the . For example, the disease has been associated with swollen eyelids and increased discharge from the eyes. "There's absolutely been an uptick in patients with foot problems," says Jackie Sutera, DPM, a podiatric surgeon with practices in New York City and Emerson, New Jersey."It's actually a little surprising, all of the problems that have trickled down, pun . "Similarly, research has shown that infection with the influenza virus poses a more severe threat for people with heart disease than those without cardiac problems. As the blood clot worsens, the skin around it often becomes red or discolored and feels warm to the touch," explains UPMC. GALVESTON, Texas New research out of Texas reports SARS-CoV-2, the virus causing COVID-19, can indeed infect the testicles. The clots in the COVID-19 patients were significantly larger and affected arteries higher up in the leg with greater frequency than those in controls. Diagnosis: (A) A 79-year-old woman manifested bilateral lower extremity swelling 1 week after COVID-19 vaccination. A person should contact a doctor if swollen lymph nodes: The outlook is positive for people who develop swollen glands after receiving an mRNA COVID-19 vaccine. Advertising on our site helps support our mission. COVID vaccine side effects can include an array of different symptoms felt on the body. Rosen's Emergency Medicine: Concepts and Clinical Practice. Ipsilateral Upper-Limb Lymphedema After COVID-19 Vaccine Booster. Inessa A. Goldman, Kenny Ye, Meir H. Scheinfeld. 6254a4d1642c605c54bf1cab17d50f1e. . Advertising revenue supports our not-for-profit mission. Clin Nucl Med. EatThis.com is part of the AllRecipes Food Group. Penn Medicine orthopedic surgeon, Christopher S. Travers, MD, shares in this video tips on how to protect your joints and manage pain during the pandemic. xhr.setRequestHeader('Content-Type', 'text/plain;charset=UTF-8'); The most common are fever, dry cough and tiredness. 2 Pain in Your Leg Thigh pain or muscle twitching or muscle cramp. Certain medicines may also cause your legs to swell. Chung JH, Hwang YJ, Park SH, Yoon ES. This content does not have an English version. Accessed Nov. 11, 2017. There have been frequent reports of DVT in the legs showing up after someone has recovered from COVID-19. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Is the ketogenic diet right for autoimmune conditions? Philadelphia, Pa.: Elsevier; 2016. https://www.clinicalkey.com. Mayo Clinic, Rochester, Minn. Nov. 8, 2017. Health challenges of her own led Joyce on a journey to discover ways to feel better through organic living, utilizing natural health strategies. A deep-bone tirednessnot just a usual sleepinesscan be a sign your heart is failing. Less is known about the virus' connection to lower extremity arterial thrombosis, a condition characterized by blood clots in the arteries that impede the flow of oxygenated blood to the lower extremities. 2022 Feb 22;19(2):e1003927. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, You have unexplained, painful swelling of your feet or legs, particularly if it's only in one leg, The swollen area becomes warm, red or inflamed, Sudden swelling along with other new signs or symptoms such as severe headache, vision changes, upper abdominal pain, nausea or vomiting, or shortness of breath. Note: Content may be edited for style and length. When a person has swollen glands due to a common virus, they may feel generally unwell as the body is fighting off an infection of some sort. "First, people with preexisting heart disease are at a greater risk for severe cardiovascular and respiratory complications from COVID-19," reported the Harvard Gazette. Typically, a person may only be able to feel their swollen lymph nodes for about 10 days after vaccination. Venous insufficiency sometimes develops in people whove had DVT in the past. When should you be concerned? What causes swollen lymph nodes in the armpit? The Centers for Disease Control and Prevention lists. Read on, and to ensure your health and the health of others, don't miss these, COVID Symptoms Usually Appear in This Order, Study Finds, With a blood clot: "You may have a persistent, throbbing cramp-like feeling in the leg. HEALTH chiefs have added a new side effect to the official list for two Covid jabs. We talked to Dr. Caputo for the rundown on some common causes of leg swelling, and what to do about them. And, wouldnt you know, you suddenly have cankles (calf-ankles) where your ankles used to be. If you press gently on your lower leg and can see your fingerprint indent for more than a few seconds, chances are, you have some excess fluid buildup, Dr. Caputo says.