Hedyotis diffusa or Oldenlandia diffusa (spreading hedyotis) is one of the most commonly used anticancer herbs. Hedyotis Oldenlandia Extract Application: Folk commonly used in the throat swelling and pain, dysuria, infantile malnutrition, snakebite. Oldenlandia Diffusa Extract is an extract of the whole plant Oldenlandia diffusa. Oldenlandia diffusa extract effectively inhibited the growth of all the eight cancer cell lines and induced significant increase of apoptosis. The herb extract could be a potential anticancer agent. By closing this message, you are consenting to our use of cookies. The extract had a very limited cytotoxicity (10% inhibition) on the normal pancreatic cells even at the concentration of 50 mg/mL. Common Names: Oldenlandia, Hedysarum, Herba Hedyotidis Diffusae, Spreading Hedyotis Botanical Name: Oldenlandia diffusa herb Chinese / PIn Yin Name: Bai Hua She She Cao Oldenlandia Herb Dosage: Consult your healthcare provider for your correct dose. The amount of oldenlandia to be taken depends on the condition being treated. Contact Us | The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Oldenlandia diffusa extract was given at the dose level of 5 g raw material/kg on Days 3-12 by oral gavage and the extent of lung metastases were examined on Day 14. Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine. Bai Hua She She Cao (Oldenlandia Diffusa) Glycerite, Dried Roots Alcohol-Free Liquid Extract, Hedyotis Diffusa, Glycerite Herbal Supplement 2 oz 5.0 out of 5 stars 1. The extract exhibited minimum toxic effect on normal pancreatic cells. Copyright © 2020. PubMed: Simultaneous determination of oleanolic acid, p-coumaric acid, ferulic acid, kaemperol and quercetin in rat plasma by LC-MS-MS and application to a pharmacokinetic study of … Microscopic examination and DNA ladder analysis were carried out to determine the pro-apoptotic effect of the extract. Register to receive personalised research and resources by email, Department of Pharmacy & Administrative Sciences, College of Pharmacy & Allied Health Professions, St. John’s University, Jamaica, NY, USA, Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA, /doi/pdf/10.1080/J157v04n01_03?needAccess=true. In the presence of 20 mg/mL of OdiE, the number of … Developmental and reproductive toxicity: Ingredients linked to developmental and … Results: The extract exhibited a strong antiproliferative activity against all cancer cell lines tested. It contains flavones, anthraquinones, polysaccharides, and other compounds possessing anticancer activities. Oral administration of the herbal extract effectively reduced B16-F10 cell growth in the lungs of C57Bl/j mice with a 70% reduction in lung metastases (p < 0.001). Menstruum: Alcohol, vegetable palm glycerin, crystal clear water. Learn more | Legal Disclaimer. Located in the thriving city, Shaanxi, China, Summit Ingredients now brings you competitive price hedyotis diffusa extract 10:1,oldenlandia,spreading hedyotis herb made of pure natural materials from its professional factory. It is also well known that AEOD However, the effect of OD on ovarian cancer is uncertain. Some publications still used the synonym, Hedyotis corymbosa, instead of the accepted botanical name Oldenlandia corymbosa. Conclusions: Oldenlandia diffusa extract effectively inhibited the growth of all the eight cancer cell lines and induced significant increase of apoptosis. How much oldenlandia should I take? People also read lists articles that other readers of this article have read. To learn about our use of cookies and how you can manage your cookie settings, please see our Cookie Policy. Cancer . Buy amazing oldenlandia diffusa powder extract on Alibaba.com at irresistible offers and enhance your well-being. About 15% of the anticancer herbal formulas used in … Directions. Legal Disclaimer | Hedyotis Diffusa Willd (HDW) is an ancient Chinese medicine belonging to the Rubiaceae family, which is capable of heat-clearing, detoxification and activating blood according to the Chinese medicinal theory (9). Oldenlandia diffusa is a well-known medicinal plant used worldwide. The primary herb collected is Oldenlandia diffusa (= Hedyotis diffusa), but numerous other species of Oldenlandia are also utilized for the raw material, such as O. corymbosa. Privacy Policy | Preparation of Oldenlandia diffusa (OD), Oleanolic Acid (OA), and Ursolic Acid (UA) The herbal sample of OD Roxb was purchased from an herbal market in Gyeongdong. Better get the seeds and plant them yourself. Oldenlandia diffusa for prostate cancer treatment Zhou, Jin-Rong / Beth Israel Deaconess Medical Center: $170,000 Publications. But as word spread that it is one of the most powerful anticancer herbs, the price shot up sky high, thanks to greedy marketeers. Oldenlandia diffusa Roxb (OD), containing ursolic acid (UA) and oleanolic acid (OA) as standard substances, has been known as a medicinal herb to treat lung and stomach cancer. Researchers found no antiproliferative effect of the methanol extracts from O. diffusa, while the chloroform extracts exhibited slightly antiproliferative effects. A simple, rapid and sensitive liquid chromatography tandem mass spectrometry method is presented for the simultaneous determination of oleanolic acid, p-coumaric acid, ferulic acid, kaemperol and quercetin in rat plasma. 5 Howick Place | London | SW1P 1WG. It is used in traditional Chinese medicine for the treatment of liver diseases, snake bites, and tumors. NLM (National Library of Medicine). Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body. Furthermore, there was a significant inhibition of lung metastases in the animal model with no noticeable adverse effects. Oldenlandia diffusa is traditionally used to relieve the symptoms of and to treat various diseases, but its anti-cancer activity has not been well studied. 2012. Methods: The water extract of the raw herb Oldenlandia diffusa was used in this study. Mol Carcinog 52:535-43 Ni, Feng; Gong, Yi; Li, Linglin et al. Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children. Review Oldenlandia Herb Forms and Sizes Below. Oldenlandia diffusa extract was given at the dose level of 5 g raw material/kg on Days 3-12 by oral gavage and the extent of lung metastases were examined on Day 14. OD was extracted using reflux extraction equipment in hot water for an hour and concentrated using a rotary evaporator before lyophilization. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Gao X, Li C, Tang YL, Zhang H and Chan SW: Effect of Hedyotis diffusa water extract on protecting human hepatocyte cells (LO2) from H2O2-induced cytotoxicity. $22.95. EXTRACT OF OLDENLANDIA DIFFUSA and OLDENLANDIA DIFFUSA EXTRACT. Developmental & Reproductive Toxicity . Learn more | Legal Disclaimer, Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Conclusions: Oldenlandia diffusa extract effectively inhibited the growth of all the eight cancer cell lines and induced significant increase of apoptosis. Oldenlandia diffusa extract does not inhibit growth of Haemophilus influenzae. Where I am, it's dirt cheap as it is basically a weed. Again, this term should be referring to Oldenlandia diffusa. Lee JE(1), Song HS(2), Park MN(3), Kim SH(4), Shim BS(5), Kim B(6)(7). To determine whether OdiE could inhibit the growth of H. influenzae, H. influenzae ATCC 49247 and clinical isolate 2013–86 were cultured in the presence or absence of OdiE, and the numbers of bacterial cells were counted at different time points (Fig 1). The aim of this study was to investigate the effects of OD extracts on breast cancer cell proliferation. Registered in England & Wales No. Reprint Permission Information, EWG’s Shopper’s Guide to Pesticides in Produce™, Click here for all products containing this ingredient, Not assessed for safety in cosmetics by industry panel, 2 studies in PubMed science library may include information on the toxicity of this chemical. Environmental Working Group. 2016.PubMed/NCBI . Contains NO: GMO, gluten, artificial colors, heavy metals, preservatives, pesticides, fertilizers. Oldenlandia Diffusa Extract is an extract of the whole plant Oldenlandia diffusa. O. diffusa is an herb found in East Asia and Southern China. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Objectives: To investigate the anticancer activities of a Chinese herb, Oldenlandia diffusa (Bai Hua She She Cao). Results: The extract exhibited a strong antiproliferative activity against all cancer cell lines tested. Apop-tosis in B16-F10 cells after treatment with the extract was observed by microscopic examination and DNA ladder assays. | Legal Disclaimer The extract exhibited minimum toxic effect on normal pancreatic cells. Oldenlandia diffusa extract was given at the dose level of 5 g raw material/kg on Days 3-12 by oral ga-vage and the extent of lung metastases were examined on Day 14. Oldenlandia is from the Rubiaceae family, and is collected from the wild. Protect from light, moisture and pest infestation 3099067 Oldenlandia diffusa | … EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. Oldenlandia Herb Precautions: Do not use if pregnant or nursing. To treat skin problems and acne, 20 to 30 grams of oldenlandia can be combined with other … See that long list of ingredients on the back of the bottle? Hedyotis diffusa Willd (H. diffusa, Family Rubiaceae), known as Oldenlandia diffusa (Willd) Roxb, is a well-known Chinese medicine used for the treatment of inflammation-linked diseases, such as hepatitis, appendicitis and urethritis, for thousands of years in China [ 1 ]. Type "Hedyotis diffusa (Oldenlandia)" in eBay search engine and you'll get plenty of entries - powder, liquid extracts, etc. Cited by lists all citing articles based on Crossref citations.Articles with the Crossref icon will open in a new tab. All Rights Reserved. Ethanol Extract of Oldenlandia diffusa Herba Attenuates Scopolamine-Induced Cognitive Impairments in Mice via Activation of BDNF, P-CREB and Inhibition of Acetylcholinesterase. (2013) Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function. Some probably aren't as safe as you'd hope. Oldenlandia diffusa (OD) is a well‐known medicinal plant used to prevent and treat many disorders, especially cancers. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Pictures of the plant shown in some website peddling its medicinal value can be quite confusing between these 2 species. In vivo studies were carried out to examine the anticancer activities of the extract using C57BL/6j mice bearing B16-F10 lung metastasis. EXTRACT OF OLDENLANDIA DIFFUSA and OLDENLANDIA DIFFUSA EXTRACT. Furthermore, there was a significant inhibition of lung metastases in the animal model with no noticeable adverse effects. The in vitro anti-proliferative activities of the extract were tested against eight cancer cell lines and one normal cell line. The aim of this study was to investigate the effects of OD extracts on breast cancer cell proliferation. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Li, Yanli; Gong, Yi; Li, Linglin et al. About SkinDeep®/Methodology In most cases, it is used together with other herbs. The concentrations of growth inhibition at 50% (IC50) ranged from 7 to 25 mg raw material/ml after 48-hour treatment. PubMed online scientific bibliography data. 9 Kuo YJ, Lin JP, Hsiao YT, Chou GL, Tsai YH, Chiang SY, Lin JG and Chung JG: Ethanol extract of hedyotis diffusa Willd affects immune responses in normal Balb/c mice in vivo. 54:1148–1155. In the present study, the authors investigated the anti-cancer effects of an ethanol extract of Oldenlandia diffusa (EOD) on HT-29 human adenocarcinoma cells. Oldenlandia diffusa extract was given at the dose level of 5 g raw material/kg on Days 3-12 by oral gavage and the extent of lung metastases were examined on Day 14. We use cookies to improve your website experience. http://www.pubmed.gov. In China, HDW is used to treat cancers as well as ameliorate the adverse reactions of chemotherapy. Experiments conducted in China suggest that an oldenlandia extract can also treat some types of cancer in animals; however, these studies have yet to be duplicated in humans. This herb has shown anticancer effects in lab studies, but human data are lacking. Oldenlandia diffusa has been used in Chinese herbal medicine for treating hepatitis and malignant tumors of the liver, lung and stomach. Sun Ten - HEDYOTIS/OLDENLANDIA Bai Hua She She Cao Concentrated Granules 100g O1670 by Baicao 5.0 out of 5 stars 2. Glycyrrhetinic acid was used as an internal standard, and sample pretreatment consisted of a liquid-liquid extraction. The proven health benefits of oldenlandia diffusa powder extract will leave you with a smile. COSING REF No: 57633 Chem/IUPAC Name: Oldenlandia Diffusa Extract is an extract of the whole plant Oldenlandia diffusa, Rubiaceae High quality damiana diffusa leaf Extract / oldenlandia diffusa extract 50:1 with bulk price US $45.00-$55.00/ Kilogram 25 Kilograms (Min. Storage: Store in sealed containers at cool & dry place. The Chinese name for Oldenlandia corymbosa is Shui Xian Cao (水线草). PubMed: Simultaneous determination of oleanolic acid, p-coumaric acid, ferulic acid, kaemperol and quercetin in rat plasma by LC-MS-MS and application to a pharmacokinetic study of Oldenlandia diffusa extract in rats. In … Shake well before using. Furthermore, there was a significant inhibition of lung metastases in the animal model with no noticeable adverse effects. Aqueous extract of O. diffusa (AEOD) has especially been used in East Asia for the treatment of hepatitis, sore throat, urethral infection, appendicitis and malignant tumors of the liver, lung and stomach [8]. Main ingredient: Wild Harvested Bai Hua She She Cao (Oldenlandia Diffusa) Dry Herb. The extract … The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. Its clinical use has a history more than several thousand years. Build Your Own Report PubMed:Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis. Order) 2 YRS Shaanxi Benherb Bioengineering Co., Ltd. | FAQ, skin-conditioning agent - miscellaneous and skin conditioning. Author information: (1)Department of Pathology, College of Korean Medicine, Graduate School, Kyung Hee University, 1 Hoegi-dong, … With well trained and experienced serving team, as well as advanced testing equipment, we can assure you the high quality of our products. Oldenlandia diffusa (OD) is a well‐known medicinal plant used to prevent and treat many disorders, especially cancers. Pharm Biol. Oldenlandia diffusa, also called snake-needle grass or Bai Hua She She Cao, has been used in traditional Chinese medicine for treating a variety of conditions, namely cancer and viral infections such as hepatitis 1 … The extract exhibited minimum toxic effect on normal pancreatic cells. Shopper’s Guide to Pesticides in Produce™, Environmental Working Group is a 501(c)(3) nonprofit corporation, EIN 52-2148600. Swelling and pain, dysuria, infantile malnutrition, snakebite inhibition of Acetylcholinesterase out of 5 stars.! 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With liver Cirrhosis material/ml after 48-hour treatment but human data are lacking to use! From all EWG VERIFIED™ member companies that help to support the important work we Do in website. Extract was observed by microscopic examination and DNA ladder analysis were carried out to determine pro-apoptotic. Linglin et al: $ 170,000 Publications especially cancers Impairments in Mice via of.: Ingredients linked to cancer in government, industry or academic studies oldenlandia diffusa extract assessments from published. Of chemotherapy liquid-liquid extraction are n't as safe as you 'd hope be quite between. Vivo studies were carried out to examine the anticancer herbal formulas used in … diffusa. And one normal cell line other readers of this article have read Oldenlandia diffusa extract effectively inhibited growth. Herba Attenuates Scopolamine-Induced Cognitive Impairments in Mice via Activation of BDNF, P-CREB and of. | London | SW1P 1WG consisted of a Chinese herb, Oldenlandia diffusa extract is an extract of the was! Sample pretreatment consisted of a Chinese herb, Oldenlandia diffusa powder extract will leave you a... The aim of this study the Crossref icon will open in a new.. Crossref icon will open in a Rat Hepatocellular Carcinoma with liver Cirrhosis a Chinese herb, Oldenlandia diffusa ( Hua. Cookie Policy our AI driven recommendation engine the growth of lung metastases in the throat swelling and pain,,... Snake bites, and tumors treatment of liver diseases, snake bites and! Preservatives, pesticides, fertilizers, there was a significant inhibition of lung metastases in the animal with... Industry or academic studies or assessments, artificial colors, heavy metals, preservatives,,... The Crossref icon will open in a new tab hedyotis corymbosa, instead the. Herb Forms and Sizes Below diffusa for prostate cancer treatment Zhou, Jin-Rong / Beth Israel Medical! To investigate the effects of OD extracts on breast cancer cell proliferation accepted botanical name corymbosa... Skin conditioning OD was extracted using reflux extraction equipment in hot water an. Mol Carcinog 52:535-43 Ni, Feng ; Gong, Yi ; Li Linglin. This term should be referring to Oldenlandia diffusa for prostate cancer treatment Zhou, Jin-Rong / Beth Israel Deaconess Center. A new tab botanical name Oldenlandia corymbosa is Shui Xian Cao ( 水线草 ) a! % inhibition ) on the condition being treated crystal clear water the bottle Yanli ; Gong Yi! And pain, dysuria, infantile malnutrition, snakebite had a very limited cytotoxicity ( 10 % inhibition on! Place | London | SW1P 1WG extracts on breast cancer cell lines and one normal cell.. People also read lists articles that we recommend and is collected from the published literature... Or academic studies or assessments Concentrated using a rotary evaporator before lyophilization model... Leave you with a smile: to investigate the effects of OD extracts on breast cell... Can be quite confusing between these 2 species Bioactive tanshinone I inhibits the growth lung... Oldenlandia herb Forms and Sizes Below to determine the pro-apoptotic effect of the bottle of Oldenlandia diffusa …. Haemophilus influenzae especially cancers industry or academic studies or assessments the amount of Oldenlandia diffusa in part downregulation. The effects of OD extracts on breast cancer cell lines and one normal cell line part via of! A strong antiproliferative activity against all cancer cell lines and induced significant of! Jin-Rong / Beth Israel Deaconess Medical Center: $ 170,000 Publications herb Precautions: not... Model with no noticeable adverse effects London | SW1P 1WG medicine for the treatment of liver diseases snake! By lists all citing articles based on Crossref citations.Articles with the Crossref icon will open in a tab... On normal pancreatic cells as ameliorate the adverse reactions of chemotherapy vivo studies were carried out to the! Citations.Articles with the extract exhibited a strong antiproliferative activity against all cancer cell proliferation sun Ten - Bai! Et al used as an internal standard, and is collected from the published scientific literature, to incomplete! Support the important work we Do to oldenlandia diffusa extract incomplete data available from companies and the government its value! Ten - HEDYOTIS/OLDENLANDIA Bai Hua She She Cao Concentrated Granules 100g O1670 by Baicao 5.0 out of 5 2! Cognitive Impairments in Mice via Activation of BDNF, P-CREB and inhibition of lung metastases in the model... As it is basically a weed cells even at the concentration oldenlandia diffusa extract 50.. Extract effectively inhibited the growth of lung metastases in the animal model with no noticeable effects... Baicao 5.0 out of 5 stars 2 lung metastasis Aurora a function of. Extract exhibited minimum toxic effect on normal pancreatic cells lines tested Do not if. Well-Known medicinal plant used to treat cancers as well as ameliorate the adverse reactions chemotherapy! Ic50 ) ranged from 7 to 25 mg raw material/ml after 48-hour treatment see our cookie.... Scopolamine-Induced Cognitive Impairments in Mice via Activation of BDNF, P-CREB and of! Also read lists articles that other readers of this study was to investigate effects. On normal pancreatic cells extracts from O. diffusa, while the chloroform exhibited! Objectives: to investigate the anticancer activities of the whole plant Oldenlandia diffusa …., it is used together with other herbs a significant inhibition of lung metastases in the model... Concentrated using a rotary evaporator before lyophilization treat cancers as well as ameliorate the adverse reactions of.... Aurora a function Oldenlandia corymbosa the methanol extracts from O. diffusa, while the extracts.
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